cervical esophageal cancer
Conditions
Interventions
Patients with cervical esophageal cancer:None
Non-tumor hospitalized patient:None
Sponsors
Suzhou Municipal Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.This study only included patients who met all three of the following criteria: 1. Primary tumor site strictly confined to the cervical esophagus. The primary tumor site must be located in the cervical esophagus, from the esophageal inlet (cricopharyngeal muscle level) to the suprasternal notch plane (approximately corresponding to the inferior margin of C6–T1 vertebral bodies). This anatomical localization must be clearly confirmed by at least one of endoscopy, enhanced CT, MRI, or surgical records. Cases originating from the thoracic, abdominal esophagus, or gastroesophageal junction (GEJ) were excluded. 2. Histopathological diagnosis of esophageal squamous cell carcinoma. All enrolled cases must be diagnosed as primary esophageal squamous cell carcinoma (ESCC) through histopathological examination of biopsy or surgical specimens. Given that squamous cell carcinoma is the predominant type of esophageal cancer in the cervical segment, adenocarcinoma, adenosquamous carcinoma, neuroendocrine carcinoma, small cell carcinoma, and other non-squamous cell carcinoma subtypes were excluded from this study to control potential interference from pathological heterogeneity on molecular analysis. 3. Patients in initial treatment and without distant metastasis. Prior to enrollment, patients had not received any local or systemic treatment for esophageal cancer, including surgery, radiotherapy, chemotherapy, targeted therapy, or immunotherapy. Clinical staging was based on the 8th edition of the AJCC/UICC TNM staging system, limited to stages I–III (TanyNanyM0), and confirmed by baseline imaging assessment (including neck ultrasound/CT, chest and abdominal enhanced CT, and whole-body PET-CT if necessary) to exclude distant metastasis.
Exclusion criteria
Exclusion criteria: 1.Those who meet any of the following conditions shall not be included: 1. The primary tumor is located in the thoracic, abdominal esophagus, or gastroesophageal junction;or the tumor grows across anatomical regions (such as involving both the cervical and thoracic esophagus), making it impossible to clearly define as a cervical primary tumor. 2. Pathological types of non-squamous cell carcinoma include adenocarcinoma, adenosquamous carcinoma, neuroendocrine tumors, small cell carcinoma, and other rare histological subtypes. 3. Having received any anti-tumor treatment for esophageal cancer before enrollment;or having confirmed distant metastasis (M1) at baseline assessment. 4. The biological sample quality does not meet the standards (such as severe degradation of DNA/RNA) or key clinical information is missing, resulting in the inability to complete the analysis of the preset study endpoints. : AI AI Primary tumor region growing Definition squamous cell carcinoma Neuroendocrine tumor small cell carcinoma and others histologymicroanatomyhyphology esophageal cancercarcinoma of esophaguscancer of the esophagus Confirmed existence[]alleged occurrence;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Genotype distribution;ß-catenin nuclear localization level; | — |
Countries
China
Contacts
Public ContactZHIQIANG LIN
Suzhou Municipal Hospital
Outcome results
None listed