Mild cognitive impairment derived from AD (MCI-AD) and AD dementia
Conditions
Interventions
AD-related MCI or dementia group:NA
Cognitively normal control group:NA
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Project participants voluntarily joined the study and signed informed consent forms; 2. Aged 50–85 years; 3. Classifiable according to the following clinical-biomarker framework: a. AD-related MCI or dementia group: Participants with subjective or objective cognitive complaints confirmed by neuropsychological assessment (e.g., MMSE = 27 points).
Exclusion criteria
Exclusion criteria: 1. Age ineligibility, inability to complete cognitive assessment scales, or inability to sign informed consent; 2. Severe psychiatric disorders (e.g., major depressive disorder, schizophrenia) or history of substance abuse; 3. Severe or unstable systemic diseases, such as advanced malignancy, severe hepatic or renal insufficiency, or uncontrolled autoimmune disease; 4. Existence of contraindications for lumbar puncture (e.g., anticoagulant use, local infection) rendering PET examination unfeasible; 5. Any other circumstances deemed by the investigator to preclude participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Limit of detection (LoD);Precision;Linearity/Range;Sensitivity;Specificity; | — |
Secondary
| Measure | Time frame |
|---|---|
| ROC-AUC;Negative likelihood ratio;Positive likelihood ratio;Stability;Total agreement rate;Interference test; | — |
Countries
China
Contacts
Public ContactJun Hu
Peking University Shenzhen Hospital
Outcome results
None listed