None
Conditions
Interventions
control group:intravenous infusion of placebo
High concentration dose group:Intravenous infusion of dimaphrine 0.1 mg/kg
Low concentration dose group:Intravenous infusion of dimaphrine 0.05 mg/kg
Sponsors
Shanghai Minhang District centeral hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Scheduled to undergo laparoscopic surgery under general anesthesia; 2. Aged 18 to 75 years; 3. ASA physical status classification I-III; 4. BMI ranging from 18 to 30 kg/m^2.
Exclusion criteria
Exclusion criteria: 1.History of anesthetic allergy reactions; 2.Pregnant or lactating women; 3.History of epilepsy or conditions increasing the risk of convulsive seizures (e.g., intracranial lesions, history of severe craniocerebral trauma, recent stroke, severe electrolyte imbalance); 4.Severe hepatic or renal insufficiency (Child-Pugh class C, eGFR 180 mmHg or DBP > 110 mmHg); 7.Severe coronary artery disease, unstable angina, recent myocardial infarction (< 6 months), uncontrolled arrhythmia, severe heart failure (NYHA Class III–IV); 8.Other conditions inappropriate for study participation (uncontrolled hyperthyroidism, pheochromocytoma, airway hyperresponsiveness or severe asthma, expected immediate postoperative ICU admission, etc.); 9.Patients who refuse to sign the informed consent form;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to modified Aldrete score = 9 after extubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| incidence of adverse events;PACU length of stay;Extubation time;respiratory kinetic changes;NRS score; | — |
Countries
China
Contacts
Public ContactLi Xiangting
Shanghai Minhang District Central Hospital
Outcome results
None listed