Intubation stimulation caused by double-lumen tracheal intubation in patients with hypertension
Conditions
Interventions
Chloroprocaine group:Chloroprocaine throat spray
Lidocaine group:Lidocaine throat spray
Sponsors
Liu'an People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age 18–65 years. 2.ASA classification II–III. 3.Clearly diagnosed with primary hypertension grade 1–2, regularly taking antihypertensive medications, with stable preoperative blood pressure. 4.Planned for elective thoracic surgery under general anesthesia, requiring routine use of a double-lumen endotracheal tube for one-lung ventilation. 5.The patient understands the study details, voluntarily agrees to participate, and signs a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Known allergy to amide or ester local anesthetics (e.g., lidocaine, chloroprocaine); 2. Concurrent severe cardiovascular disease: e.g., NYHA class III–IV heart failure, unstable angina, recent (within 3 months) myocardial infarction, severe cardiac arrhythmias; 3. Concurrent severe respiratory disease: e.g., uncontrolled asthma, severe COPD (FEV1% predicted <50%); 4. Other conditions affecting hemodynamics: e.g., uncontrolled hyperthyroidism/hypothyroidism, pheochromocytoma; 5. Long-term use of analgesic drugs or history of opioid abuse; 6. Severe hepatic or renal insufficiency (Child-Pugh class C; or eGFR <30 mL/min/1.73 m^2); 7. Cognitive impairment or psychiatric disorders that preclude cooperation with the study; 8. Pregnant or breastfeeding women; 9. Other conditions judged by the investigator to make the patient unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in mean arterial pressure (?MAP) during intubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Stress hormone levels;Changes in hemodynamic parameters (systolic blood pressure, diastolic blood pressure, heart rate, and rate-pressure product) during intubation and extubation periods;Incidence of Adverse Events; | — |
Countries
China
Contacts
Public ContactCheng Feng
Liu'an People's Hospital
Outcome results
None listed