Depressive Disorder, Bipolar Disorder
Conditions
Interventions
Depressive Disorder Patient Group:None
Health Group:None
Patient group with depressive phase of bipolar disorder:None
Sponsors
The first affiliated hostipal of nanchang university
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years old, no gender restriction; 2. Meets the diagnostic criteria for depressive disorders specified in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), confirmed by two attending physicians or above; 3. Montgomery-Åsberg Depression Rating Scale (MADRS) score >= 12 points; 4. 24-item Hamilton Depression Rating Scale (HAMD-24) score >= 8 points; 5. Meets the diagnostic criteria for bipolar disorder (Type I or Type II) in the DSM-5, with a current depressive episode, confirmed by two attending physicians or above; 6. Young Mania Rating Scale (YMRS) score < 6 points (mixed episode excluded); 7. Voluntarily participate in this study and sign the written informed consent form;
Exclusion criteria
Exclusion criteria: 1.Other mental disorders that meet the diagnostic criteria of DSM-5 (such as schizophrenia, schizoaffective disorder, obsessive-compulsive disorder, post-traumatic stress disorder, generalized anxiety disorder, panic disorder, etc.); 2.History of dependence on or current abuse of psychoactive substances (alcohol, drugs, etc.); 3.History of organic brain diseases (such as epilepsy, traumatic brain injury, intracranial infection, brain tumor, etc.); 4.Suffering from severe physical illnesses (such as malignant tumors, heart failure, renal failure, liver failure, uncontrolled diabetes, thyroid dysfunction, etc.); 5.Pregnant or lactating women; 6.Participated in other clinical studies within the past 3 months; 7.Combined with severe movement disorders or agitation that cannot cooperate with EEG/NIRS measurements;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function results. The assessed cognitive domains include attention, working memory, information processing speed and executive function.;Identification efficiency indicators; feature contribution degree;EEG Microstate Features; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Scale Scores: MARDS, YMRS, HAMA, HAMD Scores; | — |
Countries
China
Contacts
Public ContactMengqian li
The first affiliated hostipal of nanchang university
Outcome results
None listed