Hypospadias
Conditions
Interventions
Case group:None
Control group:None
Sponsors
Chongqing Health Center for Women and Children
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Case Group 1. At least one systematic ultrasound examination during the second trimester (18 to 28 weeks) indicates a suspected hypospadias in the fetus (including any of the following soft ultrasound indicators: short penis with a rounded tip, ventral curvature of the penis, positive "tulip sign", abnormal urination direction, etc.); 2. Singleton pregnancy 3. Plan to continue the pregnancy and give birth in our hospital. Control group Prenatal ultrasound examination was conducted simultaneously, and no abnormalities were found in the fetal external genitalia. 2. Singleton pregnancy 3. Plan to continue the pregnancy and give birth in our hospital; 4. Individual matching was conducted based on the age (+/-3 years) and gestational age (+/-1 week) of the pregnant women in the case group.
Exclusion criteria
Exclusion criteria: 1. Multiple pregnancies; 2. The fetus is combined with other definite structural malformations (such as congenital heart disease, neurological malformations, cleft lip and palate, etc.); 3. The fetus is diagnosed with chromosomal abnormalities (such as abnormal karyotype analysis or CNV-seq results); 4. Pregnant women suffer from severe pregnancy complications (such as severe preeclampsia, gestational diabetes requiring insulin treatment, severe autoimmune diseases, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The expression profile characteristics of metabolites in the serum and urine of pregnant women;The list and quantitative results of differential metabolites/proteins between the confirmed group and the control group;Diagnostic efficacy indicators of differential molecules: sensitivity, specificity, positive predictive value, negative predictive value, area under the curve (AUC);Clinical physical examination of newborns; | — |
Secondary
| Measure | Time frame |
|---|---|
| The correlation between the differential molecular level and the severity of hypospadias (urethral orifice location classification);Distribution characteristics of differential molecules in the ultrasound false positive group;The core metabolic pathways involved in key differential metabolites and their biological significance;Clinical information (baseline information of pregnant women, prenatal ultrasound during follow-up, postpartum information, neonatal information); | — |
Countries
China
Contacts
Public ContactGuo Chunbao
Chongqing Health Center for Women and Children
Outcome results
None listed