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The Efficacy of Intraosseous regional administration of "Cocktail" in total knee arthroplasty on perioperative pain management : A Randomized Controlled Trial

The Efficacy of Intraosseous regional administration of "Cocktail" in total knee arthroplasty on perioperative pain management : A Randomized Controlled Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600128102
Enrollment
Unknown
Registered
2026-07-14
Start date
2026-07-15
Completion date
Unknown
Last updated
2026-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee joint disease

Interventions

Group A:Periarticular infiltration 80ml "Cocktail"
Group B:Intraosseous infiltration 80ml "Cocktail"

Sponsors

Shanghai 9th People’s Hospital, Shanghai Jiao Tong University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients aged 20 to 80; 2. With an overall physical condition of I or II as assessed by the American Society of Anesthesiologists (ASA) score; 3. Clearly diagnosed with knee osteoarthritis before the operation, with symptoms mainly on one side and ineffective after conservative treatment; 4. Patients planning to undergo unilateral total knee arthroplasty (TKA) (including those who have undergone contralateral knee replacement); 5. Those who are not allergic to the drugs in this study; 6. Those willing to provide a written informed consent and participate and comply with the study.

Exclusion criteria

Exclusion criteria: 1. Patients undergoing bilateral total knee arthroplasty (TKA), unicompartmental knee joint replacement, or revision surgery; 2. Patients with severe joint lesions in both knees simultaneously; 3. Patients with severe underlying diseases and poorly controlled conditions; 4. Patients with a history of stroke or neurological or mental disorders (severe mental disorders, psychological problems, and inability to communicate); 5. Patients with a history of drug addiction, drug use, past dependence on anesthetic drugs, drug abuse history, and those currently receiving hormone therapy; 6. Patients allergic to the drugs in this study; 7. Patients with central and peripheral nervous system problems that prevent them from completing the postoperative rehabilitation plan.

Design outcomes

Primary

MeasureTime frame
VAS Score;

Secondary

MeasureTime frame
ROM of Knee;KOOC score;SF-12 Score;Concomitant medication;

Countries

China

Contacts

Public ContactZhai Zanjing

Shanghai 9th People’s Hospital, Shanghai Jiao Tong University School of Medicine

zanjing_zhai@163.com+86 21 6313 9920

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jul 23, 2026