Minimal liver syndrome
Conditions
Interventions
Observation group:NA
Sponsors
The Third Affiliated Hospital Sun Yat-sen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Type of surgery: Undergo extensive regular liver resection (such as partial liver resection, right trilobectomy, etc.), with the resection volume being = 3 standard liver segments. 2.Pathological type: Benign mass (such as giant hemangioma, focal nodular hyperplasia) or patients with primary hepatocellular carcinoma (HCC) / liver metastasis from colorectal cancer (CRLM). 3.Preoperative liver function: Child-Pugh grade A, ICG-R15 < 10%. 4.Sample requirements: Freshly frozen tissue samples from non-tumor areas (peri-tumor or background liver far from the lesion site) that are collected during the operation and properly preserved, which can meet the requirements for LC-MS/MS testing. 5.Imaging requirements: Must have high-quality preoperative baseline and early postoperative (preferably 1 month after surgery; if available, include 3 months after surgery) enhanced CT or MRI, with a slice thickness of = 2 mm, and capable of undergoing three-dimensional reconstruction.
Exclusion criteria
Exclusion criteria: 1.The postoperative pathology confirmed severe liver cirrhosis (defined as Ishak score = 5 points). 2.Before the operation, the patient had received targeted therapy, immunotherapy, systemic chemotherapy, TACE or other anti-tumor treatments that might significantly affect the background liver metabolic state and regenerative potential. 3.There occurred severe complications such as postoperative liver failure (PHLF, ISGLS grade B or C), severe bile leakage, massive intra-abdominal hemorrhage, severe infection, reoperation, or the need for long-term ICU monitoring. 4.Those who have undergone combined removal of the pancreas, stomach, intestines and other major organs. 5.There was moderate to severe obstructive jaundice or significant hyperbilirubinemia before the operation. 6.Those with insufficient liver sample volume, samples not stored in accordance with the requirements, or missing imaging data or substandard reconstruction quality.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver regeneration rate (%); | — |
Secondary
| Measure | Time frame |
|---|---|
| absolute regeneration volume (mL); differences in liver regeneration between PC high/low expression groups; | — |
Countries
China
Contacts
Public ContactLiu Wei
The Third Affiliated Hospital Sun Yat-sen University
Outcome results
None listed