Anxiety, depression
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1.Participants aged between 16 and 18 years, with no restriction on gender; 2.No psychiatric emergency or hospitalization within the past 3 months, and no history of severe mental disorders (e.g., schizophrenia, bipolar disorder); 3.Baseline mental health status meeting the following criteria: a PHQ-9 score of 5–19 for depressive symptoms and/or a GAD-7 score of 5–14 for anxiety symptoms; 4.Participants must have the basic cognitive and learning abilities necessary to complete the study and be able to independently use a smartphone, mobile application, or mini-program; 5.Participants must have at least a junior high school education (including those currently enrolled), be native Mandarin speakers, and be able to understand the study procedures and independently complete the questionnaires; 6.Participants must voluntarily agree to participate and provide written informed consent. For those under 18 years of age, written informed consent must also be obtained from their legal guardian.
Exclusion criteria
Exclusion criteria: 1.High risk of suicide (C-SSRS = 4, or clear suicidal plan/recent serious self-harm); 2.Comorbid with severe mental disorders (e.g., major depressive disorder, bipolar disorder, schizophrenia) or with moderate-to-severe autism spectrum disorder or significant intellectual disability; 3.Initiation or adjustment of antidepressant/anxiolytic medication within the past 4 weeks, or currently receiving systematic psychotherapy (=2 sessions) that may affect intervention stability; 4.Presence of severe acute or decompensated physical illness (e.g., cardiopulmonary insufficiency, acute neurological disease, or severe organic disorder) that may affect adherence or safety; 5.Substance or alcohol abuse or dependence; 6.Contraindications for medical examinations (e.g., MRI contraindications such as metal implants in the body);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression symptoms;Inflammatory factors: IL-6, TNF-a, CRP, etc.; | — |
Countries
China
Contacts
Xiangya Second Hospital, Central South University