diabetes mellitus
Conditions
Interventions
Insulin pump continuous subcutaneous insulin infusion group:None
The group with multiple daily insulin injections:None
Sponsors
The 958th Hospital of the Chinese People's Liberation Army Army
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18-70 years old; 2. Meet the diagnostic criteria for type 2 diabetes set by the World Health Organization (WHO) in 2011; 3. After lifestyle intervention and standardized treatment with two or more oral hypoglycemic drugs for at least 3 months, blood glucose remains poorly controlled, HbA1c is between 7.5% and 14.0%, or for newly diagnosed patients, HbA1c is >=9.0% or fasting blood glucose is >=11.1 mmol/L, or accompanied by obvious hyperglycemic symptoms; 4. Possess good cognitive and communication skills, and be able to understand and cooperate with the research process; 5. Fasting C-peptide level > 0.2 ng/mL; 6. Participate voluntarily and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Type 1 diabetes, gestational diabetes or other special types of diabetes; 2. Within 3 months, there were diabetic ketoacidosis, hyperglycemic hyperosmolar states, and severe hypoglycemic events; 3. There is severe heart, liver or kidney insufficiency (meeting any of the following conditions) : AST or ALT>3 times the upper limit of normal, or TBIL>1.5 times the upper limit of normal; eGFR<30ml/min/1.73m^2 or dialysis has been completed; Cardiac color Doppler ultrasound indicates LVEF<=30% or NYHA grade III or above; 4. Suffering from other serious endocrine diseases that affect blood sugar or insulin metabolism; 5. There is an active malignant tumor; 6. There are severe skin infections, allergies or conditions where wearing is not suitable at the location of the CGM sensor or insulin pump infusion pipeline. 7. Having a history of mental illness or drug or alcohol abuse, etc., and being unable to cooperate with the researcher; 8. Women who plan to become pregnant, are currently pregnant or breastfeeding during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time required for blood sugar to reach the target level;The time to reach the target blood sugar level within the specified range;The time when blood sugar is above the target range;The time when blood sugar is below the target range;Standard Deviation of Glucose;Mean Amplitude of Glycemic Excursions;glycated hemoglobin;Pancreatic islet function-related indicators (fasting C-peptide, fasting insulin levels and HOMA2 model); | — |
Secondary
| Measure | Time frame |
|---|---|
| Hypoglycemia and other adverse events;Patient treatment satisfaction;Quality of life of patients; | — |
Countries
china
Contacts
Public ContactYang Li
The 958th Hospital of the Army
Outcome results
None listed