Select patients undergoing thoracoscopic surgery with single-lung ventilation, and observe the effects of different ventilation schemes on postoperative pulmonary complications, intraoperative hypoxia, and cardiopulmonary-related adverse reactions.
Conditions
Interventions
D group:Individualized PEEP + SPO2 to regulate FiO2
C Group:Individualized PEEP + FiO2(0.8)
B Group:Fixed PEEP + SPO2 to regulate FiO2
A Group:Fixed PEEP + FiO2 (0.8)
Sponsors
Xuzhou Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective unilateral thoracoscopic surgery requiring one-lung ventilation. 2. Expected operative duration >= 60 minutes. 3. BMI ranging from 18.5 - 35 kg/m^2. 4. ASA physical status I–III. 5. Age 18–80 years old;
Exclusion criteria
Exclusion criteria: 1. Presence of severe preoperative pulmonary diseases,Chronic obstructive pulmonary disease Interstitial fibrosis, active pneumonia ,Acute respiratory distress syndrome, pulmonary bullae; 2. Severe uncontrolled cardiac or renal insufficiency; 3. Medical history of prior thoracotomy or lung resection; 4. The presence of pulmonary bullae or untreated pneumothorax are contraindications for lung re-expansion procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of comprehensive pulmonary complications 5 days after the operation.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety outcomes;Postoperative clinical endpoints;Perioperative oxygenation and arterial blood gas indicators;Intraoperative respiratory mechanics-related indicators; | — |
Countries
China
Contacts
Public ContactLiwei Wang
Xuzhou Central Hospital
Outcome results
None listed