postoperative obstetric analgesia
Conditions
Interventions
Magnesium sulfate group:Administer bupivacaine and magnesium sulphate (50 mg/h) via an epidural pump, diluted with normal saline
to 100 ml. Monitor respiratory rate and tendon reflexes
have calcium gluconate ready to counteract hypermagnesaemia.
Magnesium sulfate combined with hydromorphone group:Epidural pump infusion of bupivacaine + magnesium sulphate (25 mg/h) + hydromorphone (5 µg/h),
diluted with saline to 100 ml
Hydromorphone group:An epidural pump is used to administer bupivacaine and hydromorphone (10 µg/h), diluted with saline
to 100 ml
a bedside pulse oximeter and naloxone are provided.
Sponsors
The First Affiliated Hospital of the Baotou Medical College of Inner Mongolia University of Science and Technology
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1.aged 18–40 years 2.ASA physical status classification I–II, singleton term pregnancy (>=37 weeks) 3.elective cesarean section under combined spinal-epidural anesthesia, no contraindications to neuraxial anesthesia or history of drug allergy, signed informed consent, and voluntary participation in the study.
Exclusion criteria
Exclusion criteria: 1.Abnormal magnesium metabolism (e.g., renal insufficiency, abnormal serum magnesium levels); 2.history of opioid allergy; 3.long-term use of opioids or sedatives;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient satisfaction;Time of first press of the analgesic pump and total number of presses;Visual Analogue Scale (VAS) scores;Time to first need for additional analgesia (minutes);Time of first ambulation (hours post-operative);Sensation, recovery time from motor block;Twenty-four hours after surgery, the QoR-40 Postoperative Recovery Quality Scale was used to comprehensively assess physiological function, emotional state and other factors;Incidence of vomiting; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse reactions; | — |
Countries
China
Contacts
Public ContactGao Manhai
The First Affiliated Hospital of the Baotou Medical College of Inner Mongolia University of Science and Technology
Outcome results
None listed