Acute pain after lumbar interbody fusion surgery
Conditions
Interventions
sufentanil group:Sufentanil in the postoperative PCIA pump
oliceridine group:oliceridine in the postoperative PCIA pump
Sponsors
Zhongda Hospital, Southeast University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. ASA classification: grades I - III; 2. Age 18 - 75 years old; 3. Scheduled for elective general anesthesia for the first time for one- or two-level posterior lumbar interbody fusion; 4. Intention to use postoperative PCIA pump.
Exclusion criteria
Exclusion criteria: 1. Psychiatric disorders; 2. Preoperative cognitive impairment or communication disorders; 3. Body weight 35 kg/m^2; 4. Pregnancy or lactation; 5. History of opioid allergy; 6. Daily use of > 15 mg oral morphine equivalent within the previous 3 months, or alcohol/substance abuse; 7. Chronic non-steroidal anti-inflammatory drug (NSAID) therapy (daily use for > 2 weeks within 6 months before surgery); 8. Hepatic or renal dysfunction; 9. Diagnosed or suspected sleep apnea, or requirement for home oxygen therapy; 10. Refusal to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15 score at 24 h postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| QoR-15 scores at 1 day before surgery and 48 h postoperatively.;NRS pain scores at rest and during movement at 2, 6, 12, 24, and 48 h postoperatively.;Time to the first PCA demand (defined as the time from the end of surgery to the patient's first PCA button press).;Total number of PCA demands and successful PCA demands during the first 24 and 48 h after surgery.;Analgesic consumption from the PCA pump during the first 24 and 48 h after surgery.;Severity and incidence of postoperative nausea and/or vomiting (PONV) during the first 48 h after surgery.;Number of rescue antiemetic treatments, cumulative rescue antiemetic dose, and proportion of patients requiring rescue antiemetic therapy during the first 48 h after surgery.;Time to first flatus after surgery.;Time to first bowel movement after surgery;Time to first ambulation after surgery.;Incidence of adverse events within 48 h after surgery, including sedation, dizziness, pruritus, urinary retention, and respiratory depression.;Patient satisfaction with PCA analgesia;Length of postoperative hospital stay; | — |
Countries
China
Contacts
Public ContactQiu Lili
Zhongda Hospital, Southeast University
Outcome results
None listed