Neuropathic corneal pain after refractive surgery
Conditions
Interventions
High myopia FS-LASIK group:None
Moderate to low myopia FS-LASIK group:None
High myopia ICL group:None
Sponsors
Bejing Tongren Hospital, Capital Medical Uniersity
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. The Refractive Status Has Been Stable For >=1 Year, And The Changes In Spherical Or Cylindrical Lenses In The Past Year Have Been <=0.50D (Based On Medical Records Or Optometry Records) 2. Meet The Conventional Clinical Indications For The Intended Surgical Procedure And Have Completed The Routine Preoperative Assessment 3. High Myopia Group: -10.00 D<=SE/MRSE<= -6.00 D; Moderate To Low Myopia Group: -6.00 D<SE/MRSE<= -1.00 D 4. Willing To Cooperate With Preoperative And Postoperative Follow-Ups On D1, W1, M1, M3, M6 And M12, Along With Scale Completion
Exclusion criteria
Exclusion criteria: 1.Previous history of corneal refractive surgery, corneal transplantation, intraocular surgery or ocular trauma. 2.Active keratoconjunctival infection, severe ocular surface inflammation, uncontrolled severe dry eye, persistent corneal epithelial defect, and definite neurotrophic keratopathy. 3.Those with keratoconus or suspected keratoconus, high risk of corneal dilation and not meeting the safety requirements of FS-LASIK; In the ICL group, there were patients with abnormal anterior chamber depth, corneal endothelial cells, anterior chamber Angle or intraocular pressure that did not meet the safety requirements of ICL surgery. 4.Conditions such as diabetic peripheral neuropathy, active stage of severe autoimmune diseases, fibromyalgia, severe chronic pain syndrome, and severe neurological disorders that may significantly interfere with pain assessment. 5.Those who are using systemic drugs for a long time that may significantly affect the ocular surface or pain perception, and the researchers determine that confounding cannot be controlled; Antihistamines and antidepressants/antianxiety drugs are not excluded in all cases, but they must be recorded in detail and used as covariates. 6.Those with obvious mental and neurological symptoms, cognitive impairment, language communication disorders or inability to independently complete the scale. 7.Pregnant or lactating women. 8.Visitors who cannot stop wearing contact lenses as required or are expected to be unable to complete long-term follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tear inflammatory factors and neurotransmitters;Neurological function and imaging;Symptoms and psychological covariates;Objective ocular surface examination; | — |
Countries
China
Contacts
Public ContactYuan jin
Bejing Tongren Hospital, Capital Medical Uniersity
Outcome results
None listed