Pulmonary tuberculosis (PTB)
Conditions
Interventions
The group receiving combined nasopharyngeal airway and high-flow nasal cannula oxygen therapy (NP-HFNC group):None
The high-flow nasal cannula (HFNC) group:None
The group receiving combined nasopharyngeal airway and high-frequency jet ventilation (NP-HFJV group):None
Sponsors
Chongqing Public Health Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Eligible participants were patients with pulmonary tuberculosis who were scheduled to undergo elective lesion cryotherapy and biopsy under painless bronchoscopy in our hospital; 2. Aged 18-75 years old; 3. American Society of Anesthesiologists (ASA) physical status classification of grade I-III; 4. All patients voluntarily signed the written informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients planned to undergo rigid bronchoscopy diagnosis and treatment as well as thermal therapy; 2. Patients with high-risk airway factors: severe airway stenosis, acute upper respiratory tract infection, or nasal/pharyngeal anatomical malformations (e.g., severe nasal septal deviation); 3. Patients with severe cardiopulmonary diseases: chronic obstructive pulmonary disease (COPD) GOLD grade III-IV, uncontrolled asthma or pulmonary hypertension (mPAP > 60 mmHg); cardiac insufficiency (NYHA grade III-IV) or acute coronary syndrome within 6 months; 4. Patients with contraindications to Permissive Hypercapnia (PHC): increased intracranial pressure, severe arrhythmia, severe metabolic acidosis, active epilepsy or brain diseases, early postoperative patients after craniocerebral trauma or neurosurgery; 5. Patients with other systemic diseases: severe obesity (BMI > 35 kg/m^2), coagulation disorders (INR > 1.5 or platelet 45 mmHg); 8. Patients with hearing, intellectual, communication or cognitive disorders (i.e., lack of informed consent capacity); 9. Patients who cannot cooperate with the study for any reason or are considered unsuitable for participation by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peripheral oxygen saturation (SpO2, %); | — |
Secondary
| Measure | Time frame |
|---|---|
| Complications included adverse events such as sore throat, epistaxis, and subcutaneous emphysema.;Arterial partial pressure of carbon dioxide (PaCO2, mm Hg);Blood pressure and heart rate; | — |
Countries
China
Contacts
Public ContactRongdan Tan
Chongqing Public Health Medical Center
Outcome results
None listed