None
Conditions
Interventions
Experimental group:Esketamine was administered in combination with remimazolam for intravenous anesthesia
Sponsors
Jiangsu Province Hospital (The First Affiliated Hospital with Nanjing Medical University)
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged 65–80 years; 2.American Society of Anesthesiologists (ASA) physical status class II–III; 3.Body mass index (BMI) 18.5–28.0 kg/m^2; 4.Scheduled for elective sedated gastrointestinal endoscopy; 5.Able to comprehend the study protocol, voluntarily agree to participate, and provide written informed consent personally signed by the participant
Exclusion criteria
Exclusion criteria: 1.Presence of language, visual, hearing, mental, psychological, or neurological impairments that preclude effective communication, provision of informed consent, or cooperation with the endoscopic procedure; 2.Occurrence of cerebrovascular accident, myocardial infarction, or unstable angina within the past 3 months, or presence of severe cardiac, hepatic, or renal dysfunction; 3.Presence of significant high-risk factors for the airway or respiratory system, such as severe obstructive sleep apnea, a history of difficult airway, or acute or severe bronchial asthma; 4.Allergy or contraindication to remimazolam, esketamine, or propofol; 5.Use of opioids, sedative-hypnotics, or other centrally active medications that may affect sedation or respiratory assessment within the past 48 hours; 6.Chronic pain or cancer pain requiring long-term analgesic medication; 7.Participation in other drug clinical trials within the past 3 months; 8.Any other condition deemed by the investigator to be unsuitable for participation in this study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient Responses During Gastroscopy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate;Esketamine dose;Total dose of remimazolam;Recovery Time;Discharge Time;Mean Arterial Pressure;Adverse Events;Pulse oximetry saturation;Examination Duration; | — |
Countries
China
Contacts
Public ContactChun Yang
Jiangsu Province Hospital (The First Affiliated Hospital with Nanjing Medical University)
Outcome results
None listed