Nasopharyngeal carcinoma
Conditions
Interventions
Control group:Conventional follow-up
Intervention group:Multimodal integrated assessment-guided follow-up intervention
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Patients with histologically confirmed nasopharyngeal carcinoma at initial diagnosis, classified as stage N3 (any T stage, N3 disease according to the 9th edition of the AJCC/UICC staging system) without evidence of distant metastasis; 2.No prior history of neck lymph node dissection; 3.Age between 18 and 70 years; 4.Satisfactory performance status with an Eastern Cooperative Oncology Group (ECOG) score of 0–1; 5.Adequate organ function, defined as leukocyte count >= 4.0 × 10^9/L, absolute neutrophil count >= 2.0 × 10^9/L, hemoglobin >= 90 g/L, platelet count >= 100 × 10^9/L, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels = 60 mL/min; 6.The ability to be fully informed about the study and provide written informed consent.
Exclusion criteria
Exclusion criteria: 1.Patients who have received other antitumor therapies or are currently participating in other interventional clinical trials. 2.Pregnant or lactating women; 3.Any serious comorbid conditions or risk factors that may lead to unacceptable risks or affect study compliance, such as severe cardiac disease (NYHA class III–IV), severe pulmonary dysfunction (grade 3 or higher), renal disease, or severe psychiatric disorders. 4.Except for adequately treated basal cell carcinoma of the skin, carcinoma in situ of the cervix, and superficial bladder tumors (Ta, Tis, and T1), patients with a history of other invasive malignancies within the past 5 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Failure-Free Survival, FFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Locoregional recurrence-free survival, LRRFS;Overall Survival, OS;Distant Metastasis-Free Survival, DMFS;Adverse Events; | — |
Countries
China
Contacts
Public ContactXuelei Ma
West China Hospital of Sichuan University
Outcome results
None listed