Osteoporosis, sarcopenia,Osteosarcopenia
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1.Aged >=60 years and -2.5 and <=-1.0 at any measured site; (2) Osteoporosis defined as a T-score <=-2.5 at any measured site; 4.Diagnosed with sarcopenia, defined as low appendicular skeletal muscle mass combined with reduced muscle strength and/or impaired physical performance; 5.Appendicular skeletal muscle mass measured using DXA, with the appendicular skeletal muscle index (ASMI) calculated as appendicular skeletal muscle mass divided by height squared. Low muscle mass is defined as: (1) ASMI<7.0 kg/m^2 for men; (2) ASMI<5.5 kg/m^2 for women; 6.Able to complete basic low-to-moderate intensity exercise training with safety supervision or assistance when necessary; 7.Able to use a smartphone and WeChat for study communication, exercise management, and follow-up; 8.Able to understand the study objectives, procedures, potential benefits, and risks, and willing to participate voluntarily; 9.Able and willing to provide written informed consent.
Exclusion criteria
Exclusion criteria: 1.A fragility fracture, major trauma, or musculoskeletal surgery within the previous 6 months; 2.Severe cardiovascular or respiratory disease that may increase exercise-related risk or interfere with implementation of the exercise intervention; 3.Severe neurological, hepatic, renal, endocrine, or metabolic disease that may affect study outcomes, exercise safety, or adherence; 4.Severe visual impairment, vestibular dysfunction, or another condition that substantially affects balance, walking ability, or exercise safety; 5.Severe cognitive impairment, psychiatric disorder, or communication impairment that prevents understanding of the study requirements, participation in the intervention, or completion of outcome assessments; 6.Secondary osteoporosis clearly caused by malignant tumors, radiotherapy, chemotherapy, long-term glucocorticoid use, or another severe endocrine or metabolic disorder; 7.Neurogenic low back pain, severe spinal stenosis, spinal cord or nerve root compression, or another spinal disorder requiring surgical treatment; 8.Severe joint pain, marked limitation of movement, or another contraindication to exercise that prevents safe completion of the prescribed training program; 9.Current participation in another interventional clinical study or receipt of a systematic and structured exercise or rehabilitation program that may influence the study outcomes; 10.Inability to maintain the existing anti-osteoporosis medication regimen during the study, or an anticipated need for additional treatment that may substantially affect the study outcomes; 11.Considered unsuitable for participation by the research team or treating physician based on the participant’s overall health status.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in bodily functions; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain intensity;Activities of daily living;Bone density;Balance ability;Muscle mass;Health-related quality of life; | — |
Countries
China
Contacts
Wuhan Sports University