Delayed awakening and disturbance of consciousness after general anesthesia
Conditions
Interventions
Patients receiving Propofol intravenous anesthesia:None
Sponsors
Xuzhou Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18-65 years; 2.ASA I class; 3.Elective, laparoscopic surgery estimated to last 2-4 hours; 4.Able to understand and voluntarily sign written informed consent.
Exclusion criteria
Exclusion criteria: 1.History of any diagnosed mental disorder that may affect cognition or mood; 2.History of neurological disease; 3.Skull or scalp injuries or defects, or skin diseases or anatomical abnormalities that may affect stable wearing of the EEG cap and accurate positioning of the TMS; 4.Having metal implants in the body; 5.Long-term use of any drug that may affect the central nervous system; abuse of alcohol or psychoactive substances; 6.Have a history of allergy to propofol or other drugs planned to be used in the trial; 7.Body mass index > 35 kg/m²; 8.There is a clear history of sleep disorders or severe circadian rhythm disruption; 9.Severe anemia, coagulation disorder, or severe liver and kidney dysfunction; 10.It is expected that drugs that may interfere with electroencephalography or the recovery of consciousness will need to be used during the operation, or the patient refuses to accept the intensive TMS-EEG monitoring and multiple venous blood collection specified in the protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| recovery neurodynamic slope; | — |
Secondary
| Measure | Time frame |
|---|---|
| Riker Sedation-Agitation Scor;3-minute delirium diagnostic scale;recovery quality scale;Post-Anesthesia Care Unit(PACU) stay time;full wake time;Numerical Pain Rating;Dynamic slope of weighted phase lag index between prefrontal-parietal brain regions in the theta frequency band (4-8 Hz) during recovery period;Montreal Cognitive Assessment;Open your eyes as instructed;Resting period Lempel-Ziv complexity values measured every minute during the recovery period; | — |
Countries
China
Contacts
Public ContactZan Wang
Xuzhou Central Hospital
Outcome results
None listed