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miR-24/AKS1/GSDME Axis Regulates Inflammation, Apoptosis, and Pyroptosis in Asthma

miR-24/AKS1/GSDME Axis RegulatesInflammation, Apoptosis, and Pyroptosis in Asthma

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600127933
Enrollment
Unknown
Registered
2026-07-10
Start date
2026-07-10
Completion date
Unknown
Last updated
2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bronchial asthma

Interventions

Asthma group:None
Health group:None

Sponsors

Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 16 Years

Inclusion criteria

Inclusion criteria: This study involved children aged 0-16: 20 in the healthy group, 60 in the asthma remission group, and 60 in the severe asthma progression group. All children were diagnosed according to the Global Initiative for Asthma (GINA) guidelines. An acute asthma attack was defined as acute or subacute symptoms related to airflow obstruction, while the remission phase meant no asthma symptoms were reported and no related medications were used.

Exclusion criteria

Exclusion criteria: Exclusion criteria include having severe infections, autoimmune diseases, other respiratory diseases, or a history of malignant tumors.

Design outcomes

Primary

MeasureTime frame
miR-24, ASK1, and GSDME Expression Levels;—

Countries

China

Contacts

Public ContactJianmin Ye

Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

yejianmin@xinhuamed.com.cn+86 21 2507 8999

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jul 23, 2026