Alzheimer‘s disease
Conditions
Interventions
Experimental group:Cerebellar intermittent theta burst stimulation (iTBS)
Control group: Sham stimulation
Sponsors
The First Affiliated Hospital of Air Force Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age: 50–80 years old; 2. MMSE score between 18–26, Clinical Dementia Rating (CDR) score of 0.5–1; Hamilton Depression Rating Scale (HAM-D) score =14; 3. Meet the NIA-AA criteria established by the U.S. National Institute on Aging; cerebrospinal fluid shows increased Aß and decreased tau protein. 4. Have been on a stable dose of a cholinesterase inhibitor (such as donepezil or galantamine) for at least 6 weeks, with no dose changes needed during the intervention and observation period; 5. Able to cooperate with treatment and related examinations; 6. Patient and family voluntarily sign the informed consent form
Exclusion criteria
Exclusion criteria: 1. Unable to cooperate to complete treatment and various tests 2. Having serious infections, epilepsy, cerebrovascular diseases, malignant tumors, or serious heart, liver, kidney dysfunction, mental disorders, alcoholism, drug dependence, or psychiatric illnesses 3. Having contraindications for transcranial magnetic stimulation and MRI, such as metal or implanted devices in the body, like pacemakers or deep brain stimulators 4. Participating in another clinical trial at the same time 5. Patient or family withdraws informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from Baseline in Clinical Dementia Rating Scale Sum of Boxes (CDR-SB); | — |
Secondary
| Measure | Time frame |
|---|---|
| Change from Baseline in Delayed Matching-to-Sample (DMS) task performance and simultaneous electroencephalography (EEG) features;Change from Baseline in Mini-Mental State Examination (MMSE) score;Change from Baseline in Alzheimer‘s Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) score;Change from Baseline in Activities of Daily Living (ADL) scale score;Change from Baseline in Neuropsychiatric Inventory (NPI) total score;Changes on magnetic resonance imaging (MRI) before and after treatment; | — |
Countries
China
Contacts
Public ContactWen Jiang
The First Affiliated Hospital of Air Force Medical University
Outcome results
None listed