Chronic Pelvic Pain Syndrome
Conditions
Interventions
Chronic Pelvic Pain Syndrome group:None
Healthy control group:None
Sponsors
Peking University People's Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for subjects with chronic pelvic pain syndrome (CPPS):; 1.Adult males aged 18–65 years; 2.Meet the National Institutes of Health (NIH) diagnostic criteria for chronic pelvic pain syndrome (CPPS) , with recurrent (more than once per week) pain in the genital, perineal, suprapubic, or anal region for at least the past 6 months, and the pain cannot be explained by another medical diagnosis; 3.Presence of pelvic floor muscle trigger points, tension bands, or obvious tenderness confirmed by rectal examination; 4.Visual Analogue Scale (VAS) score >= 3; 5.Able to cooperate with examinations and sign informed consent; Inclusion criteria for healthy subjects: 1.Adult males aged 18–65 years; 2.No trigger points, tension bands, or obvious tenderness in the pelvic floor muscles confirmed by rectal examination; 3.Self-reported absence of persistent or recurrent pelvic pain (pain locations including the perineum, genitals, suprapubic region, or perianal area); 4.No abnormal urination (e.g., frequency, urgency, dysuria), no abnormal defecation (e.g., chronic constipation, painful defecation), and no sexual dysfunction (self-assessment of normal erectile and ejaculatory function); 5.Ability to correctly perform pelvic floor muscle contraction and Valsalva maneuver, and to independently complete all questionnaire assessments; 6.No use of any medications that may affect pelvic floor muscle tone or pain perception (e.g., muscle relaxants, opioids, tricyclic antidepressants, etc.) within 4 weeks prior to enrollment;
Exclusion criteria
Exclusion criteria: Exclusion criteria for subjects with chronic pelvic pain syndrome (CPPS):; 1.Clear alternative etiology (e.g., infection, stones, tumor, interstitial cystitis, inflammatory bowel disease, etc.); 2.History of urogenital surgery; 3.Neurological or musculoskeletal diseases affecting pelvic floor function; 4.Presence of severe anxiety or depression (HADS score above the cut-off, e.g., >= 11); 5.Use of any medications that may affect pelvic floor muscle tone or pain perception (e.g., muscle relaxants, opioids, tricyclic antidepressants, etc.) within 4 weeks prior to enrollment; 6.Inability to perform pelvic floor muscle contraction or Valsalva maneuver; Exclusion criteria for healthy subjects:; 1.History of urogenital surgery; 2.Previous history of definite organic diseases that may cause pelvic pain, such as prostatitis, epididymitis, or varicocele; 3.Low cognitive level that prevents cooperation with questionnaire assessments; 4.Presence of severe anxiety or depression (HADS score above the cut-off, e.g., >= 11);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Levator plate angle;Anorectal angle; | — |
Secondary
| Measure | Time frame |
|---|---|
| Scoring of clinical symptom and psychological state scales;Displacement of pelvic floor structures; | — |
Countries
China
Contacts
Public ContactLiu Yiming
Peking University People's Hospital
Outcome results
None listed