postoperation pain
Conditions
Interventions
Liposomal bupivacaine group:10 mL of 0.5% bupivacaine hydrochloride and 10 mL of 1.33% liposomal bupivacaine
Bupivacaine Hydrochloride Group:10 mL of 0.5% bupivacaine hydrochloride and 10 mL of 0.9% normal saline
Sponsors
Ganzhou People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-80 years old; 2. ASA (American Society of Anesthesiologists) classification I-I; 3. BMI between 18kg/m^2and 30kg/m^2; 4. Patients scheduled for elective unilateral knee replacement surgery; 5. Aware of the purpose of the study, voluntarily participate, and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Allergy to bupivacaine or contraindications to local anesthetics; 2.Impaired cognitive or mental status, unable to communicate effectively; 3.History of chronic pain or opioid use for more than 3 months; 4.Severe cardiac, hepatic or renal disease; 5.Infection at the puncture site;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of rebound pain;The difference in pain scores before and after regression of block between the two groups; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to onset of rebound pain;Pain intensity at rest and during activity was assessed using the NRS at 12, 24, 48, and 72 hours postoperatively;Number of rescue analgesic administrations;Cumulative dosage of opioid analgesics within 72 hours postoperatively;Patient satisfaction with pain control; | — |
Countries
China
Contacts
Public ContactBaolin Zhong
Ganzhou People's Hospital
Outcome results
None listed