Elderly Patients Undergoing Noncardiac Surgery
Conditions
Interventions
Dopamine group:3 mg/kg of dopamine diluted in 50 mL normal saline
Control group:Equal volume of normal saline
Sponsors
Dongguan Tungwah Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age >=65 years 2. Weight >=50 kg 3. ASA classification >=II 4. Elective non-cardiac surgery under general anesthesia (digestive, hepatobiliary, urological, ENT, orthopedic, or gynecological)
Exclusion criteria
Exclusion criteria: 1. Emergency surgery 2. Uncontrolled hypertension (systolic blood pressure >150 mmHg) 3. Acute cardiovascular event within the preceding 3 months (myocardial infarction/stroke) 4. eGFR <30 mL·min?¹·1.73 m?² or long-term dialysis 5. Severe hepatic insufficiency (Child-Pugh Class C) 6. Preoperative sepsis or shock 7. Ongoing continuous norepinephrine infusion 8. Regional anesthesia sufficient to complete the surgical procedure 9. Known hypersensitivity to dopamine, ephedrine, or any protocol-related medications 10. Inability to provide informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the curve (AUC) of mean arterial pressure (MAP) below 65 mmHg within 15 minutes following anesthetic induction (mmHg·min); | — |
Secondary
| Measure | Time frame |
|---|---|
| AUC and duration for different MAP thresholds (100, >110, >120, >140 mmHg);[] Vasopressor dosage / Vasoactive agent dosage;Length of hospital stay (LOS);Hemorrhage/Transfusion;New-onset or worsening cardiac arrhythmia within 24 hours postoperatively; | — |
Countries
China
Contacts
Public ContactXianghua Cao
Department of Anesthesiology, Dongguan Tungwah Hospital, Dongguan, Guangdong, China
Outcome results
None listed