Aortic Stenosis
Conditions
Interventions
Group E:Add esmolol to the hyperkalemic cardioplegic solution
Group C:Add placebo to the hyperkalemic cardioplegic solution
Sponsors
Sichuan Academy of Medical Sciences · Sichuan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Age >= 18 years; Cardiac function classification (NYHA) II-IV grade; Patients scheduled for elective open-heart simple aortic valve replacement; Diagnosed with left ventricular hypertrophy: Male: Left ventricular mass index (LVMI) > 115 g/m². Female: (LVMI) > 95 g/m².
Exclusion criteria
Exclusion criteria: Age < 18 years; Emergency surgery; Pregnant or lactating women; Patients with severe liver or kidney dysfunction; Patients with unstable preoperative hemodynamics (such as cardiogenic shock); Patients allergic or contraindicated to beta-blockers (such as severe bradycardia, high atrioventricular block, cardiogenic shock, acute asthma attack); Patients undergoing other cardiac surgeries at the same time; Patients undergoing a second aortic valve replacement; Patients who agree to other interventional trials; Patients that the researchers consider to have any other conditions unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The area under the curve of hs-cTnI 48 hours after the operation;30-Day Postoperative All-Cause Mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of malignant arrhythmia;Time for the heart to relapse;Automatic bounce rate;Positive muscle strength medication use;Left ventricular function;Mechanical ventilation time;Length of stay in ICU;Postoperative new-onset atrial fibrillation;Low cardiac output syndrome; | — |
Countries
China
Contacts
Public ContactLv Qiang
Sichuan Academy of Medical Sciences · Sichuan Provincial People's Hospital
Outcome results
None listed