Amyotrophic lateral sclerosis
Conditions
Interventions
ALS mimics group:NA
Control group:NA
ALS group:NA
Sponsors
The first affiliated hostipal of nanchang university
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with ALS, MND, ALS-like syndromes, or exclusionary neurological injuries who sought treatment during the study enrollment period or whose medical records and data are available in this medical center’s medical records and database. 2. For ALS patients, the 2000 revised El Escorial diagnostic criteria must be met (clinically confirmed, highly probable, or highly probable with laboratory support). For other MND patients, they must meet the diagnostic criteria for relevant subtypes such as progressive bulbar palsy, isolated bulbar-onset ALS, flaccid-flaccid syndrome, or primary lateral sclerosis.
Exclusion criteria
Exclusion criteria: 1. Incomplete cranial MRI scans or poor image quality that prevents quantitative analysis; 2. Cases with significant cerebral small-vessel disease (high signal intensity in the subcortical white matter), cerebral hemorrhage, severe cerebral atrophy, or motion artifacts that prevent SWI quantification. Cases with comorbid neurological disorders that may interfere with cortical iron deposition (e.g., Alzheimer’s disease, severe Parkinson’s disease, etc.); 3. Incomplete clinical records (e.g., missing information on disease duration, site of onset, scale scores, or physical examination findings); 4. Patients with psychiatric disorders, severe cognitive impairment, concomitant multi-organ dysfunction, or in a critically ill condition, where data collection and assessment cannot be completed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical diagnostic evaluation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Disease monitoring; | — |
Countries
China
Contacts
Public ContactZhu Yu
The first affiliated hostipal of nanchang university
Outcome results
None listed