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Analgesic effect of transcutaneous auricular vagus nerve stimulation during routine colonoscopy: a multicenter, single-blind, randomized controlled trial

Analgesic effect of transcutaneous auricular vagus nerve stimulation during routine colonoscopy: a multicenter, single-blind, randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600127898
Enrollment
Unknown
Registered
2026-07-09
Start date
2026-07-09
Completion date
Unknown
Last updated
2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non anesthetized colonoscope subjects

Interventions

Experimental Group 1:taVNS treatment in concha with frequency parameter of 100Hz
Experimental Group 2:taVNS treatment in concha with frequency parameter of 25Hz
Control group:Stimulation of the non-concha region of the auricle

Sponsors

The first affiliated hospital of USTC
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.Age range: 18-75 years old; 2.Patients who meet the criteria for colonoscopy examination (including those who have undergone physical examination, have chronic abdominal distension and pain, and have changed bowel habits; patients with long-term symptoms such as urgency and chronic diarrhea, etc.); 3.Elderly people >= 60 years old must have good cardiovascular and pulmonary function, stable vital signs, and be accompanied by family members; 4.Voluntarily participate in this study and sign an informed consent form.

Exclusion criteria

Exclusion criteria: 1.Patients with active gastrointestinal bleeding; 2.Chronic constipation patients; 3.Patients with speech and cognitive impairments; 4.Suffering from malignant tumors of the intestine, anorectal stenosis affecting endoscopic examination, acute infection of the anorectal tract, acute peritonitis, acute active inflammatory diseases of colitis, acute diverticulitis, etc; People with severe purulent inflammation or painful lesions in the anus or rectum who cannot tolerate examination; 5.Merge serious primary diseases that endanger life, such as cardiovascular, cerebrovascular, liver, kidney, as well as psychiatric patients; 6.Menstrual, pregnant, and lactating women; 7.Active tuberculosis patients, patients with significant coagulation dysfunction (such as hemophilia patients), and patients with advanced malignant tumors; 8.Diabetes patients; People who have implanted pacemakers or defibrillators in their bodies; 9.Not reaching full colon examination; 10.Long term or 24-hour use of sedatives or analgesics; 11.Pain VAS score >= 3 before examination.

Design outcomes

Primary

MeasureTime frame
Visual Analogue Scale;

Secondary

MeasureTime frame
Colonoscopy time;Average heart rate, blood oxygen, respiratory rate;High scoring events with VAS score = 6;Satisfaction rating;

Countries

China

Contacts

Public ContactYu Yue

The first affiliated hospital of USTC

yuyuedoctor@163.com+86 189 6378 8891

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jul 23, 2026