Chronic obstructive pulmonary disease
Conditions
Interventions
Healthy Control group:None
Sponsors
Shaoxing People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age =18 years; 2.Confirmed diagnosis of COPD, currently experiencing an acute exacerbation (AECOPD); 3.Blood and sputum samples can be collected within 24 hours of hospital admission or emergency department presentation; 4.Signed informed consent form;
Exclusion criteria
Exclusion criteria: 1.Severe hepatic or renal impairment; 2.Active malignancy or ongoing radiotherapy/chemotherapy; 3.Pregnancy or lactation; 4.Use of high-dose immunosuppressants or systemic glucocorticoids within the past month; 5.Symptoms caused by acute non-COPD conditions (e.g., acute left heart failure, pulmonary embolism); 6.Inability to collect a sample or an unsuitable sample;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency and severity of AECOPD;Exogenous chemical exposure profiles in blood and sputum; | — |
Secondary
| Measure | Time frame |
|---|---|
| CAT and mMRC scores;Inflammatory biomarkers including CRP, IL-6, IL-8, and TNF-a;Blood gas parameters including PaO?, PaCO?, and pH;Lung function parameters including FEV1 and PEF;Mixture effects of multiple exposures; | — |
Countries
China
Contacts
Public ContactLi Jingli
Shaoxing People’s Hospital
Outcome results
None listed