Breast diseases
Conditions
Interventions
Intervention Group (Group B):Bupivacaine liposome (1.33%, 10ml) + standard bupivacaine hydrochloride (0.5%, 10ml)
Control Group (Group C):Standard bupivacaine hydrochloride (0.5%, 20ml)
Sponsors
The Second Hospital of Lanzhou University
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Gender is not limited. Age: 18 to 70 years old. 2. BMI: 18-28kg/m^2; 3. ASA is classified into grades I to III; 4. Proposed surgery: Unilateral breast surgery (radical mastectomy/modified radical mastectomy/breast-conserving + sentinel lymph node biopsy/axillary dissection).
Exclusion criteria
Exclusion criteria: 1.Known to be allergic to (amides), liposomes or related excipients; 2.Infection at the puncture site, coagulation dysfunction (INR>1.4, platelet <80×10^9/L), or the use of anticoagulant drugs. 3.Severe liver and kidney dysfunction (Child-Pugh grade C, or eGFR<30 ml/min/1.73m^2); 4.Recent history of painkiller intake and drug abuse; 5. Severe scoliosis, deformity or history of thoracic spine surgery; 6. Pregnant or lactating women; 7. Inability to understand or use the pain scoring scale; 8.Those suffering from mental disorders or other diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS Pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of analgesia;The consumption of opioids;Adverse reactions;Adverse reactions; | — |
Countries
China
Contacts
Public ContactWang Yingbin
The Second Hospital of Lanzhou University
Outcome results
None listed