Subthreshold Depression
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Current university students aged 18 years or older. 2. Initial screening using the CES-D scale indicating subthreshold depressive symptoms, and suitability for participation confirmed through a one-on-one interview with the research staff. 3. Normal or corrected-to-normal vision and hearing; no color blindness or color weakness. Right-handed. 4. No history of major psychiatric disorders and able to understand the study procedures, complete questionnaires, cognitive tasks, MRI scanning, and hair sample collection. 5. Voluntary participation with signed written informed consent.
Exclusion criteria
Exclusion criteria: 1. Does not meet MRI participation requirements, including but not limited to the presence of metallic implants unsuitable for MRI, pacemakers, claustrophobia, or other MRI contraindications. 2. Color blindness, color weakness, or inability to complete visual emotional stimulus tasks. 3. History of major psychiatric disorders, or current screening/interview indicates prominent psychotic symptoms, risk of manic episodes, severe self-harm or suicide risk, or other conditions unsuitable for participation. 4. Under 18 years of age. 5. Left-handed or ambidextrous. 6. Use of psychiatric medications within the past two weeks. 7. Poor physical condition on the day of the experiment, or in the past three days not suitable for MRI scanning or psychological tasks. 8. Unable to complete the experimental procedures as required, or dropout during the pre- to post-test period, making full participation impossible. 9. Data failing to meet minimum quality standards, such as extensive missing questionnaire data, invalid responses in cognitive tasks, severe head motion or artifacts in MRI data, or missing/untraceable hair sample records.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary psychological scales;Sleep and emotion-related questionnaires;Neuroendocrine measures; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive-behavioral tasks;MRI measures; | — |
Countries
China
Contacts
Nanjing Normal University