Esophageal cancer, gastric cancer, colon cancer
Conditions
Interventions
Index test:Based on the screened DNA methylation, CNV, and fragment features, machine learning methods such as logistic regression are used to construct early screening models (including tumor predict
Sponsors
Beijing Chest Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age between 30 and 80 years old; 2. Participants must be able to undergo endoscopy and other related tests; 3. Healthy control participants need to have negative endoscopy and/or pathology results, no other cancers, and must not have had previous endoscopy results showing gastrointestinal tumors (esophageal, gastric, or colorectal cancer) or precancerous lesions; 4. Participants with gastrointestinal tumors (esophageal, gastric, or colorectal cancer) or precancerous lesions must be diagnosed via endoscopy and/or pathology, should not have other systemic or organ malignancies, and must not have had surgery, radiotherapy, or chemotherapy before blood collection; 5. Other cancers (including but not limited to lung, breast, and liver cancer) must be primary, single-type cancers, and participants must not have had surgery, radiotherapy, or chemotherapy before blood collection; 6. Benign diseases include irritable bowel syndrome, mild to moderate atrophic gastritis, reflux esophagitis, etc.; 7. Participants must fully understand the nature of this study, the related tests, and any risks of participation, and be able to comprehend and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. The blood sample volume is too small, less than 8 mL, making DNA methylation testing and WGS sequencing impossible; 2. Incomplete information about the blood sample (including sample collection time, sample number, participant's age, gender, medical history, imaging results, endoscopy, and pathology results, etc.); 3. Blood sample quality control fails, including samples that don’t meet collection and processing requirements, repeatedly frozen and thawed, hemolyzed, contaminated by microbes, tested with problematic reagents (expired, contaminated, improperly stored, etc.), or other human errors during testing; 4. Pregnant women, breastfeeding women, or women planning to conceive; 5. Any situation the study doctor considers unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DNA methylation region;cfDNA fragment features;Copy Number Variation; | — |
Countries
China
Contacts
Public ContactYuqi He
Beijing Chest Hospital, Capital Medical University
Outcome results
None listed