None
Conditions
Interventions
Remimazolam grou:Use remifentanil for anesthesia induction and maintenance
Propofol group:Use propofol for anesthesia induction and maintenance
R1 group:Anesthesia was maintained using remifentanil at a rate of 0.6 mg/(kg·h)
R2 group:Anesthesia was maintained using remifentanil at a rate of 0.65 mg/(kg·h)
R3 group:Anesthesia was maintained using remifentanil at a rate of 0.7 mg/(kg·h)
R4 group:Anesthesia was maintained using remifentanil at a rate of 0.75 mg/(kg·h)
R5 group:Anesthesia was maintained using remifentanil at a rate of 0.8 mg/(kg·h)
Sponsors
Central Theater Command General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age between 18 and 65 years old; 2. Body Mass Index (BMI) within 18.5 - 23.9 kg/m^2; 3. ASA classification of grades I - III; 4. Patients undergoing suboccipital tumor resection had the surgery performed by the same group of physicians; 5.The estimated operation time is less than 5 hours; 6.Normal preoperative neurological function.
Exclusion criteria
Exclusion criteria: 1. The patient refused. 2. Has a history of epilepsy. 3. Severe impairment of liver and kidney functions. 4.History of long-term alcohol consumption or use of sedative drugs. 5. Patients with severe neuromuscular damage as assessed by preoperative electrophysiological examination. 6. Severe respiratory and cardiovascular diseases, with history of cardiac pacemaker implantation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The latency and amplitude of sensory evoked potentials;Latency and amplitude of motor evoked potentials;Electromyographic amplitude;Latency of auditory evoked potential;bispectral index;The dosage of propofol used;The dosage of remimazolam;Number of times for blood pressure and heart rate warning during the perioperative period; | — |
Secondary
| Measure | Time frame |
|---|---|
| heart rate;mean arterial pressure;Postoperative recovery time;anesthesia related complication;Duration of the surgery;Perioperative fluid intake and output; | — |
Countries
China
Contacts
Public ContactLi Bixi
Central Theater Command General Hospital
Outcome results
None listed