Prostate Cancer
Conditions
Interventions
Group E (esketamine group):Low opioid anesthesia with esketamine
Group C (conventional opioid group):Conventional opioid anesthesia
Sponsors
Dalian Municipal Central Hospital
Eligibility
Sex/Gender
Male
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Patients planned to undergo elective robot-assisted laparoscopic radical prostatectomy under general anesthesia; 2. Age between 60 and 85 years old; 3. BMI 18-28 kg/m^2; 4. ASA class I to III; 5. Agree to participate in this study and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. People with a history of opioid abuse or long-term use of opioids/sedatives; 2. Those with serious respiratory depression, an acute exacerbation of chronic obstructive pulmonary disease, status asthmaticus, or other relative contraindications to opioids; 3. Those with severe liver or kidney dysfunction; 4. People with central nervous system injuries, a history of mental illness, or preoperative cognitive/hearing impairments making assessment difficult; 5. Anyone allergic to esketamine or the anesthetics involved in this study; 6. Those with serious cardiovascular disease, uncontrolled hypertension, or hyperthyroidism; 7. Cases where researchers believe there might be other anesthesia risks or situations making participation in this study inappropriate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-40 Scale Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hospital Anxiety and Depression Scale (HADS) score (including anxiety [HADS-A] and depression [HADS-D] subscales);The total number of compressions, and salvage analgesia rate of Patient Controlled Intravenous Analgesia (PCIA) pump;Montreal Cognitive Assessment (MoCA) score;Hemodynamic parameters (heart rate, mean arterial pressure, pulse oximetry);Dosage of propofol, remifentanil, and sufentanil, as well as the use of central vascular drugs during surgery;Incidence of postoperative adverse reactions;Postoperative recovery related indicators;Visual Analog Scale (VAS) pain rating in resting and exercise (cough) states;the incidence of hypotension and bradycardia;Ramsay Sedation Rating;incidence of anxiety and depression; | — |
Countries
China
Contacts
Public ContactLiping Han
Dalian Municipal Central Hospital
Outcome results
None listed