Hematological malignancies, CAR-T therapy-related cytokine release syndrome (CRS)
Conditions
Interventions
Observation group:None
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients with hematological malignancies who received CAR-T treatment; 2.Age >= 18 years.
Exclusion criteria
Exclusion criteria: 1.Patients with hematopoietic stem cell transplantation bridging CAR-T treatment; 2.Patients with incomplete vital signs after CAR-T infusion;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence of cytokine release syndrome ( CRS );Onset time of Cytokine Release Syndrome (CRS);Severity grading of Cytokine Release Syndrome (CRS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensitivity of the early identification of CRS by the early warning system;Specificity of the early identification of CRS by the early warning system;Adverse events (such as fever, hypotension, and breathing difficulties); | — |
Countries
China
Contacts
Public ContactHuang Baokui
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed