Treatment-resistant depression
Conditions
Interventions
Sham a-iTBS stimulation group:Sham stimulation
Active a-iTBS stimulation group:Active stimulation
Sponsors
Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Age 18–55, any gender; 2. According to the MINI (International Neuropsychiatric Interview), meet the DSM-V criteria for TRD; 3. HAMD-24 total score >= 20; 4. Have taken at least two different types of antidepressants for 4 weeks each without effect; 5. Fully understand the safety of Ti, willing to actively cooperate with treatment, and consent signed by both the patient and family.
Exclusion criteria
Exclusion criteria: 1. A history of serious physical illnesses or depression caused by other psychoactive or non-dependent substances; 2. Presence of movement system diseases, including Parkinson’s disease, spinal cord injury, spasms, Huntington’s disease, muscular dystrophy, or osteoarthritis; 3. Risk of epilepsy, history of brain disease, head trauma, alcohol abuse, abnormal EEG, evidence of structural brain abnormalities on MRI, or a family history of epilepsy; 4. Presence of psychotic symptoms requiring treatment with antipsychotic medications; 5. Receiving ECT, TMS, or tES treatments, or systemic psychotherapy within the 3 months before enrollment; 6. Abnormalities in physical exam, medical history, vital signs, routine blood/urine/stool tests, liver and kidney function, electrolytes, ECG, EEG, or other indicators; 7. Presence of metal or electronic devices in the body, such as intracranial metal fragments, cochlear implants, pacemakers, or stents.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of Depressive Symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| Electrophysiological indicators including brain region activation, functional connectivity, cortical plasticity, etc.;motor assessment;Other Core Symptoms of Depression; | — |
Countries
China
Contacts
Public ContactDongsheng Zhou
Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed