Colorectal cancer combined with liver cirrhosis
Conditions
Interventions
control group:None
Sponsors
Mengchao Hepatobilary Hospital of Fujian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with liver cirrhosis based on imaging, laboratory tests, and clinical history ; 2. Patients with newly diagnosed primary CRC confirmed by pathology and assessed tumor staging as stage I-III (i.e. no distant metastasis) ; 3. Intending to undergo elective radical surgery for colorectal cancer with informed consent from the patient/legal representative.
Exclusion criteria
Exclusion criteria: 1. Emergency surgery patients (e.g., requiring urgent surgery due to intestinal obstruction, perforation, massive bleeding, etc.); 2. Patients with severe dysfunction of other vital organs (e.g., severe cardiac insufficiency (NYHA class III-IV), chronic kidney disease stage IV-V, etc.); 3. Patients with other uncontrolled malignant tumors; 4. History of major abdominal surgery; 5. Unstable state of decompensated cirrhosis (e.g., acute variceal bleeding within 4 weeks before surgery, acute hepatic encephalopathy (grade 2 or above), acute bacterial peritonitis, etc.); 6. Patients suspected of hereditary colorectal cancer; 7. Patients unable to cooperate with the study or follow-up;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of severe postoperative complications within 30 days (Clavien-Dindo grade =3); | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary clinical endpoints within 30 days postoperatively (reoperation rate, readmission rate, mortality, length of hospital stay, ICU admission rate and duration, total medical costs within 30 days;Liver reserve function related indicators (Child Pugh, MELD, etc.);Peripheral blood biomarkers of inflammation, immunity and liver fibrosis; | — |
Countries
China
Contacts
Public ContactLin Suyong
Mengchao Hepatobilary Hospital of Fujian Medical University
Outcome results
None listed