Neonatal Necrotizing Enterocolitis
Conditions
Interventions
Control group:Conventional allogeneic blood transfusion
Intervention group:Autologous cord blood reinfusion
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: 1. Gestational age = 14 days 4.Informed consent signed by the guardian;
Exclusion criteria
Exclusion criteria: 1. Maternal presence of severe infection (e.g., clinically diagnosed chorioamnionitis, sepsis, or active infection) or bloodborne infectious diseases (e.g., active phase of HBV, HCV, HIV, or other conditions deemed by the investigator to be unsuitable for cord blood collection and reinfusion) 2. Congenital gastrointestinal malformations 3.Severe chromosomal abnormalities or lethal malformations 4.Severe birth asphyxia requiring prolonged resuscitation 5.Failure to successfully preserve a usable cord blood specimen 6. Voluntary withdrawal or loss to follow-up during the study period 7.Refusal of the family to participate in the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of necrotizing enterocolitis (NEC = stage 2) (according to the Bell staging criteria); | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of Retinopathy of Prematurity;Time to achieve full enteral nutrition;Incidence of late-onset sepsis (LOS);Mortality rate during hospitalization;Bronchopulmonary dysplasia (BPD) incidence (according to the 2001 and 2019 criteria);Number of transfusions;Incidence of intraventricular hemorrhage (IVH > grade 2) (according to the Papile classification);Transfusion-related adverse reactions;Length of hospital stay;Total transfusion volume;Incidence of Periventricular Leukomalacia;Rate of weight gain; | — |
Countries
China
Contacts
Public ContactQi Hongbo
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed