ADHD with sleep-wake rhythm disorder
Conditions
Interventions
Intervention group:On the basis of the original rehabilitation treatment and daytime oral medication treatment, for three consecutive days, at 22:00, dexmedetomidine at a dose of 1 µ g/kg was sprayed
Control Group:On the basis of the original rehabilitation treatment and daytime oral medication, for three consecutive days, at 22:00, nasal spray 1 µ g/kg of normal saline. Divide the total volume of
Sponsors
Wuhan Childrens Hospital
Eligibility
Sex/Gender
All
Age
6 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1.Patients diagnosed with ADHD using the DSM-5 criteria 2.Gender is not limited. Age: 6 to 12 years old. 3.ASA classification grades I - II; 4. ADHD patients diagnosed with sleep-wake rhythm disorder using the Early Morning and Nighttime Scale (MEQ-19) <40; 5. The guardian of the patient voluntarily accepted the relevant treatment plan of this study and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Individuals allergic to DEX; 2.Combining special diseases such as sleep apnea syndrome, restless leg syndrome, or somatic pain that can easily cause insomnia; 3.Those who are not suitable for nasal spray administration due to severe rhinitis, nasal malformation, severe asthma, etc; 4.Individuals with heart conduction block or cardiac dysfunction detected by dynamic electrocardiogram examination; 5.After admission, routine examination revealed the presence of other serious organic diseases and mental illnesses; 6.Other individuals who do not meet the inclusion criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sleep quality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Score of the Attention Deficit Hyperactivity Disorder Screening Scale (SNAP-IV);The content of melatonin in blood and saliva;The content of brain-derived neurotrophic factor (BDNF) in blood;Circadian rhythms;Safety evaluation; | — |
Countries
China
Contacts
Public ContactKong Fanli
Wuhan Childrens Hospital
Outcome results
None listed