Postoperative pain after posterior lumbar fusion surgery
Conditions
Interventions
Oliceridine Group:Patient-Controlled Intravenous Analgesia with Oliceridine
Sufentanil Group:Patient-Controlled Intravenous Analgesia with Sufentanil and Ondansetron
Sponsors
The Second Qilu Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age 18–65 years, any gender. 2.Diagnosed with lumbar disc herniation, lumbar spinal stenosis, or lumbarspondylolisthesis,scheduled for elective single-level or two-level posterior lumbar fusion. 3.American Society of Anesthesiologists (ASA) physical status classification I–III. 4.No history of chronic pain before surgery; no long-term use of opioids, non-steroidal anti-inflammatory drugs (NSAIDs), or sedative-hypnotics. 5.Clear consciousness, able to understand and cooperate with VAS (Visual Analog Scale) scoring, Ramsay sedation scale assessment, and questionnaire surveys. 6.Voluntarily signed written informed consent and willingness to complete the entire study.
Exclusion criteria
Exclusion criteria: 1.Allergy to oliceridine, sufentanil, or other components of the analgesic pump (e.g., normal saline, antiemetics). 2.Preoperative significant respiratory insufficiency (FEV1 2 times the upper limit of normal, serum creatinine >133 µmol/L). 3.Presence of coagulation disorders, history of peptic ulcer, or recent bleeding tendency. 4.History of drug abuse, psychiatric disorders, or cognitive impairment. 5.Pregnant or lactating women. 6.Anticipated operative time exceeding 4 hours, intraoperative blood loss >800 mL, or requiring postoperative admission to the intensive care unit (ICU). 7.Concomitantacute pain at other sites, or development of severe postoperative complications (e.g., infection, loosening of internal fixation) that affect pain assessment. 8.Refusal to use intravenous patient-controlled analgesia (PCA) pump, or inability to cooperate with follow-up observations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS pain score at rest at 24 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative Quality of Recovery-15 (QoR-15) Scores at 24 and 48 Hours;Incidence of Postoperative Respiratory Depression;ncidence of Postoperative Nausea and Vomiting (PONV);Number of Patient-Controlled Analgesia (PCA) Pump Demands;Time to First Ambulation and Length of Hospital Stay;Postoperative Analgesia Satisfaction;Postoperative Resting Visual Analogue Scale (VAS) Scores at Multiple Time Points; | — |
Countries
China
Contacts
Public ContactXin Zhao
The Second Qilu Hospital of Shandong University
Outcome results
None listed