patients undergoing their first allogeneic kidney transplantation
Conditions
Interventions
Intervention group:Ultrasound-guided transversus abdominis plane block (TAP) was performed on the surgical side. 10ml of 1.3% bupivacaine liposome and 20ml of normal saline were injected. The needle t
Control group:30ml of traditional 0.25% bupivacaine was used, and the operation norms were the same as those of the experimental group.
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years; 2. BMI 18.5-28 kg/m^2; 3. ASA class II-III; 4. Diagnosed with end-stage renal disease (eGFR 3 months); 5. Receiving a first allogeneic kidney transplant; 6. Cold ischemia time of the donor kidney <=24 hours; 7. Planned to undergo retroperitoneal approach kidney transplantation; 8. Resting systolic blood pressure <=160 mmHg and diastolic blood pressure <=100 mmHg; 9. Discontinue NSAIDs 72 hours before surgery.
Exclusion criteria
Exclusion criteria: 1. Received iodinated contrast agent examination within 72 hours before kidney transplantation (serum creatinine fluctuation >=0.3 mg/dL); 2. Multiple renal artery anastomoses (>=3 vessels) or intraoperative hypersensitivity reaction (pathologically confirmed); 3. Long-term opioid dependence (>30 mg/day morphine equivalent for >=1 month); 4. Abnormal coagulation: INR>1.5 or platelet count <80×10^9/L; 5. History of abdominal surgery: metal implants/extensive adhesions in the block area; 6. History of local anesthetic allergy: history of allergic reaction to bupivacaine/ropivacaine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The 72-hour postoperative creatinine decline rate (?Cre72 = (Cre24 ? Cre72) × 100 / Cre24); | — |
Secondary
| Measure | Time frame |
|---|---|
| 72-hour postoperative cumulative opioid consumption (in morphine equivalents);Respiratory depression event;Estimated glomerular filtration rate (eGFR) on postoperative day 7;48-hour postoperative serum NGAL;Postoperative pain scores at rest and during cough at 24, 48, and 72 hours (Numerical Rating Scale, NRS);Incidence of postoperative nausea and vomiting (PONV);Cumulative number of rescue analgesia episodes within 72 hours postoperatively.;24-hour postoperative urinary a-GST/p-GST;Incidence of delayed graft function (DGF);Manifestations of local anesthetic-induced neurotoxicity;The 48-hour postoperative creatinine decline rate (?Cre48 = (Cre24 ? Cre48) × 100 / Cre24); | — |
Countries
China
Contacts
Public ContactDu Hailiang
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed