Septic Shock
Conditions
Interventions
Control Group:Standard Fluid Therapy Strategy
Intervention Group:Precision Fluid Therapy Strategy
Observation Group:None
Sponsors
Ruijin-Hainan Hospital Shanghai Jiao Tong University School of Medicine (Hainan Boao Research Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for septic shock according to Sepsis-3 definition; 2. Aged >= 18 years; 3. The patient or their legal representative has voluntarily signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Aged < 18 years, or pregnant or lactating women; 2. Primary immune deficiency disorders; active autoimmune diseases receiving immunosuppressive therapy; HIV infection with CD4 count < 200/µL; active hematologic malignancies; 3. Long-term immunosuppressive status, including long-term use of glucocorticoids or other potent immunosuppressants (e.g., cyclosporine, tacrolimus, cyclophosphamide) before ICU admission, or post-organ transplant status; 4. End-stage disease with expected survival < 24 hours, or decision to pursue palliative care; 5. Receipt of experimental therapies that may significantly interfere with immune function assessment prior to enrollment; 6. Presence of other severe comorbidities: Child-Pugh Class C cirrhosis, end-stage renal disease requiring dialysis, or severe cardiac dysfunction (NYHA Class IV);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-Day All-Cause Mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of Vasopressor Use;Duration of Renal Replacement Therapy;Total Hospital Cost;Cost-Effectiveness Ratio;Incidence of Acute Kidney Injury;ICU Length of Stay;Incidence of Ventilator-Associated Pneumonia;Duration of Mechanical Ventilation; | — |
Countries
China
Contacts
Public ContactLiu Yiyun
Ruijin-Hainan Hospital Shanghai Jiao Tong University School of Medicine (Hainan Boao Research Hospital)
Outcome results
None listed