Dentofacial Deformity
Conditions
Interventions
Esketamine group:Intraoperative esketamine administration
Saline group:Intraoperative saline administration
Sponsors
Peking University Hospital of Stomatology
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 60 years old; 2. ASA physical status classification I or II; 3. Patients scheduled for elective bimaxillary orthognathic surgery; 4. Voluntary participation with signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with known hypersensitivity to esketamine; 2. Patients with a history of schizophrenia, epilepsy, or long-term use of antidepressants/sedative-hypnotics; 3. Recent history of drug or alcohol abuse; 4. Patients with preoperative chronic pain or long-term opioid administration; 5. Patients with severe hepatic or renal insufficiency, or severe cardiovascular diseases; 6. Pregnant or breastfeeding women; 7. Patients with any preoperative cognitive or language impairment that impedes communication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15 score at 24 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Use of postoperative rescue analgesics;Incidence of adverse events;QoR-15 score at 72 hours after surgery;Postoperative Sleep Quality Score (RCSQ Scale);Postoperative NRS pain score;postoperative nausea and vomiting;Postoperative anxiety and depression status (HADS Scale);Satisfaction score;Use of postoperative antiemetics; | — |
Countries
China
Contacts
Public ContactLiu Qiao
Peking University Hospital of Stomatology
Outcome results
None listed