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A Randomized Controlled Study of Anchored Endoscopic Mucosal Resection versus Conventional Endoscopic Mucosal Resection for the Treatment of Large Pedicle-Free Colorectal Polyps

A Randomized Controlled Study of Anchored Endoscopic Mucosal Resection versus Conventional Endoscopic Mucosal Resection for the Treatment of Large Pedicle-Free Colorectal Polyps

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600127783
Enrollment
Unknown
Registered
2026-07-07
Start date
2026-05-27
Completion date
Unknown
Last updated
2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal polyps

Interventions

Conventional-EMR Group:Conventional-EMR
Anchored-EMR Group:Anchored-EMR

Sponsors

Meizhou People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.Colonoscopy confirms the presence of polyps with a diameter >=10 mm, and pathological biopsy (if performed preoperatively) or postoperative pathology confirms colorectal polyps (adenomatous polyps, hyperplastic polyps, inflammatory polyps, etc.), with the polyp morphology being sessile (Paris classification types 0-IIa, 0-IIb, or 0-Is). The patient has an American Society of Anesthesiologists (ASA) physical status classification of I-III and is able to tolerate endoscopic surgery. Age 18-75 years, with no gender restrictions. The patient and their family understand the study content and voluntarily sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1.The polyp has undergone cancerous transformation (pathology indicates intramucosal carcinoma or invasive carcinoma) or is suspected of malignancy (such as ulceration on the polyp surface, firm texture, or unclear margins). Presence of severe dysfunction in vital organs such as the heart, liver, or kidneys (e.g., heart failure NYHA class =IV, decompensated cirrhosis, chronic kidney failure stage 5). Coagulation abnormalities (prothrombin time >14 seconds, activated partial thromboplastin time >40 seconds, platelet count <100×10?/L) or long-term use of anticoagulants or antiplatelet drugs (warfarin, rivaroxaban, aspirin, clopidogrel) with discontinuation <7 days. Poor bowel preparation quality (Boston Bowel Preparation Scale score <6), unable to clearly expose the polyp. Comorbid conditions such as intestinal stenosis, intestinal obstruction, perforation, or acute intestinal infection. Psychiatric disorders, cognitive impairment, or communication difficulties that hinder cooperation with surgery and follow-up. History of colorectal surgery (excluding polypectomy) or inflammatory bowel disease (ulcerative colitis, Crohn's disease).

Design outcomes

Primary

MeasureTime frame
En Bloc Resection Rate;Complete Polyp Resection Rate;R0 Resection Rate;

Secondary

MeasureTime frame
Intraoperative Blood Loss;Postoperative Complication Rate;Piecemeal Resection Rate;Postoperative Polyp Recurrence Rate;

Countries

China

Contacts

Public ContactZhong Xiongping

Meizhou People's Hospital

515984164@qq.com+86 753 2202723

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jul 23, 2026