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A single-arm, multi-centre, phase II clinical study on the efficacy and safety of pomadomide + CD20 monoantibo combined with CHOP regimen in the treatment of primary DLBCL

A single-arm, multi-centre, phase II clinical study on the efficacy and safety of pomadomide + CD20 monoantibo combined with CHOP regimen in the treatment of primary DLBCL

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600127766
Enrollment
Unknown
Registered
2026-07-07
Start date
2025-12-14
Completion date
Unknown
Last updated
2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diffuse large B-cell lymphoma.

Interventions

Sponsors

Henan Cancer Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.Diagnosed as DLBCL through histopathological examination, using the classification system of the World Health Organization (WHO); 2. Has not previously received treatment for DLBCL; 3. The projected lifespan exceeds 3 months; 4. 18<=age=<75 years, with no gender restrictions; 5. The absolute neutrophil count should be at least 500/µL, and the platelet count should be at least 50,000/µL; 6.If the subject is of reproductive age, effective contraceptive measures must be employed, and they must agree to comply with all contraceptive requirements; 7.The observer signed the informed consent form for the experimental treatment.

Exclusion criteria

Exclusion criteria: 1.Women who are pregnant or breastfeeding (breastfeeding women must agree not to breastfeed while taking pomalidomide); 2.Individuals known to be allergic to the components of the experimental drug; 3.Combine severely affected individuals; 4. The researcher considers the individual unsuitable for inclusion in the study.

Design outcomes

Primary

MeasureTime frame
Objective response rate at the end of induction therapy.;

Secondary

MeasureTime frame
Objective response rate at the end of maintenance therapy.;PFS;OS;DOR;

Countries

China

Contacts

Public ContactQingsong Yin

Henan Cancer Hospital

jnyinqingsong@163.com+86 371 6558 7358

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jul 23, 2026