Post-induction hypotension (PIH)
Conditions
Interventions
Propofol-Young group (Group PY):Control group (Propofol) : General anesthesia induction with propofol was performed, and propofol was injected at a dose of 2 mg/kg within 30 seconds
Ciprofol-Young group (Group CY):Intervention group (Ciprofol) : General anesthesia induction was performed using cyclopofol, with 0.4mg/kg administered within 30 seconds
Propofol-Elderly group (Group PE):Control group (Propofol) : General anesthesia induction with propofol was performed, and propofol was injected at a dose of 2 mg/kg within 30 seconds
Ciprofol-Elderly group (Group CE):Control group (Propofol) : General anesthesia induction with propofol was performed, and propofol was injected at a dose of 2 mg/kg within 30 seconds
Sponsors
The Affiliated Hospital of Weifang Medical University
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients scheduled for elective surgery under general anesthesia who voluntarily provide written informed consent; 2.Both sexes, aged 20–40 years (young group) or 65–80 years (elderly group), with an American Society of Anesthesiologists (ASA) physical status class of I or II; 3. Body Mass Index (BMI) between 18 and 28 kg/m^2; 4.Presence of normal sinus rhythm, capable of cooperating with FloTrac continuous hemodynamic monitoring, and no significant history of cardiovascular disease.
Exclusion criteria
Exclusion criteria: 1.Cognitive impairment (e.g., dementia) precluding the ability to provide informed consent; 2.Known severe cardiovascular diseases (e.g., heart failure, severe coronary artery lesions, irreversible arrhythmias), or severe respiratory, hepatic, or renal dysfunction; 3.Severely abnormal baseline blood pressure (Systolic Blood Pressure, SBP > 180 mmHg); 4.Patients requiring bolus administration of vasopressors or emergency clinical intervention due to severe hypotension or ventilation difficulties (Oxygen Saturation, SpO2 < 94%) during the induction period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the curve (AUC) of hypotension;Cumulative dose of vasopressors during the induction period; | — |
Secondary
| Measure | Time frame |
|---|---|
| HR, CO, SV, SVR, SVV, and BIS values at each time point (T0–T5) during the induction period.;Time to loss of consciousness (T-LOC), defined as the time interval from the start of study drug injection until the loss of eyelash reflex.;The percent change ( %? ) of hemodynamic parameters from baseline (T0) to 2 minutes after study drug injection (T2).;Incidence of hypotension; | — |
Countries
China
Contacts
Public ContactWang Dewei
The Affiliated Hospital of Weifang Medical University
Outcome results
None listed