Stress
Conditions
Interventions
Acute stress:None
Chronic stress:None
Healthy control:None
University students (art therapy):None
High-stress occupation:None
Sponsors
Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Clinical scenarios Inclusion criteria: 1. At least 18 years old, with full civil capacity, clear awareness, able to understand the research content and cooperate in completing the assessment; 2. Acute Stress Group (ICD-11 ARS): professionally assessed by a psychiatrist, meeting the diagnostic criteria for "Acute Stress Reaction (ARS)" in the 11th edition of the International Classification of Diseases (ICD-11) (specific course requirements must be provided, such as symptoms occurring within hours to days after a recent major stress event, and duration meeting the ARS definition); 3. Chronic Stress Group (ICD-11 PTSD/Depression/Anxiety): Professionally assessed by a psychiatrist and meeting any of the following diagnostic criteria in ICD-11: Post-Traumatic Stress Disorder (PTSD); Depressive Disorders; Anxiety Disorders; It is necessary to clarify the course of the disease, such as symptoms lasting at least X weeks/month and currently in the flare-up phase or not yet in remission; 4. Health control group: assessed by a psychiatrist, with no history of mental disorders (including ICD-11 defined mental or behavioral disorders), and no significant psychological distress (e.g., no depression/anxiety symptoms or symptom levels below clinical threshold confirmed by standardized screening tools); 5. Voluntarily participate in this study, sign a written informed consent form, and be able to understand and independently complete the required questionnaires (or with family assistance; if the subject has mild cognitive impairment but is determined by a physician not to affect core assessment). 2. Student scenarios Inclusion criteria: 1. Full-time university students aged 18 or above; 2. Voluntarily participate in this study and sign the informed consent form, able to understand and complete the questionnaire.
Exclusion criteria
Exclusion criteria: 1. Clinical scenarios Exclusion criteria: 1. History of severe mental illness: Current or past clearly diagnosed severe mental illness, including but not limited to: (1) Major depressive disorder with psychotic symptoms, bipolar disorder type I/II (current or past manic/depressive episodes), schizophrenia spectrum and other psychotic disorders (corresponding to ICD-11 codes); (2) Other mental disorders that may cause severe cognitive impairment or inability to cooperate with assessments (such as organic mental disorders, delirium, etc.); 2. Medication interference: Systematically taking the following medications within the past month that may affect stress responses or psychological assessment results: (1) Antidepressants (such as SSRIs, SNRIs, tricycloids, etc.); (2) Anti-anxiety drugs (such as benzodiazepines, buspirone, etc.); (3) Glucocorticoids (such as prednisone, dexamethasone, etc., as they may affect mood and stress physiological indicators); If the subject has taken the above drugs but stopped for more than one month, they may be considered after a physician's assessment that the drug residue effect has been eliminated; 3. Severe or unstable physical diseases, including but not limited to: endocrine diseases, autoimmune diseases, cardiovascular diseases (recent relevant examination reports must be provided; if the subject's physical condition is stable and confirmed by a specialist that does not affect psychological assessment, the investigator may decide whether to include them); 4. History of alcohol dependence, drug abuse (such as marijuana, opioids, stimulants, etc.), or alcohol/substance abuse within the past 6 months; 5. Pregnant or breastfeeding women; 6. Severe cognitive impairment that prevents understanding the scale content or cooperating with the assessment. 2. Student scenarios Exclusion criteria: 1. Current or past history of major depressive disorder, bipolar disorder, schizophrenia, or other serious mental illnesses with a clear diagnosis; 2. Systematic use of antidepressants, anxiolytics, or glucocorticoids within the past month; 3. Severe or unstable physical illnesses (such as endocrine diseases, autoimmune diseases, cardiovascular diseases); 4. History of alcohol or substance abuse; 5. Pregnant or breastfeeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Salivary cortisol ;epinephrine;norepinephrine;Cortisol awakening response; instantaneous fluctuation rate;Self Rating Depression Scale;Self?Rating Anxiety Scale;Perceived Stress Scale; accuracy of the AI model; | — |
Secondary
| Measure | Time frame |
|---|---|
| E/NE ratio;E/cortisol ratio; | — |
Countries
China
Contacts
Public ContactZhang Chunyan
Chinese PLA General Hospital
Outcome results
None listed