Recurrent implantation failure
Conditions
Interventions
Morphology-only group:Morphological embryo selection
IDAScore group:IDAScore embryo scoring combined with morphological embryo selection
Sponsors
Renji Hospital affiliated to Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1.Infertile women with a history of RIF, RIF refers to failure to achieve a clinical pregnancy (including Biochemical pregnancy abortion) after one of the following conditions: (1) 3 or more embryo transfer cycles (2) 2 embryo transfer cycles where no less than 3 embryos were transferred cumulatively; 2. Women aged 20-40 years at the time of OPU; 3. Women with at least 2 blastocysts; 4.Be capable of giving informed consent.
Exclusion criteria
Exclusion criteria: 1.Women with a uterine cavity abnormality, such as a uterine congenital malformation (uterus unicornate, bicornate, or duplex) , untreated uterine septum, submucous myoma, multiple endometrial polyp(s) or with a history of severe intrauterine adhesions, with untreated hydrosalpinx, with thin endometrium (< 6 mm on the trigger day). 2.Women who are indicated and planned to undergo PGT-A, PGT-M or PGT-SR; 3.Women who use donated oocytes to achieve pregnancy; 4.Women with medical contraindications to assisted reproductive technology and/or pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live birth after the first embryo transfer cycle; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neonatal complications, birth weight and birth defects;Biochemical pregnancy;Complications during pregnancy and childbirth;Good birth outcome;Pregnancy loss;Clinical pregnancy; | — |
Countries
China
Contacts
Public ContactHuang Jia'an
Renji Hospital affiliated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed