Acute cerebral infarction
Conditions
Interventions
RIC+Passive Exercise group:RIC is administered twice daily for 7 days, starting within 24 hours after stroke onset or symptom worsening. Passive exercise training begins on day 3 and is conducted once
RIC+Sham-Passive exercise group:RIC is administered twice daily for 7 days, starting within 24 hours after stroke onset or symptom worsening. Sham passive exercise training begins on day 3 and is per
Passive exercise group:Sham passive exercise training begins on Day 3 after stroke onset or symptom worsening and is performed once daily for 5 days.
Sponsors
Affiliated Hospital of Jiujiang University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years; 2.Patients diagnosed with acute ischemic stroke within 0–24 hours of onset; 3.Study intervention can be initiated within 24 hours of symptom onset; 4.NIHSS score >= 4; 5.Informed consent form signed by either the patients themselves or their legally authorized representatives.
Exclusion criteria
Exclusion criteria: 1. Contraindications to ischemic conditioning therapy (1)Skin/soft tissue injury, fractures, or peripheral arterial disease in upper limbs; 2. Unstable vital signs (1)Systolic blood pressure 220 mmHg; (2)Heart rate 100 bpm; (3)Percutaneous oxygen saturation (SpO2) =92%; (4)Body temperature =38.5°C; 3. Upper limb fractures or other conditions preventing exercise training completion; 4. Underlying diseases and relevant treatment history (1)History of autoimmune diseases or malignancy; (2)Immunosuppressant use within the last 3 months; 5. Poor prognosis (1)Life expectancy =1 year; 6. Major organ dysfunction (1)Severe hepatic, pulmonary, cardiac, or renal dysfunction; 7. Bleeding and coagulation abnormalities (1)Coagulopathy or active bleeding; 8. Severe cardiovascular emergencies (1)Concurrent acute coronary syndrome or severe arrhythmia; 9. Lower extremity vascular disease (1)Venous thrombosis in both lower limbs; 10. Special physiological status in females (1)Known pregnancy, lactation, or positive pregnancy test; 11. Concurrent participation in other clinical trials (1)Concurrent enrollment in other drug or device clinical studies; 12. Other ineligible conditions (1)Other conditions deemed ineligible by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified Rankin Scale Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| National Institute of Health stroke scale score;Barthel Index score;Water Swallowing Test ;Activity of Daily Living score;Glasgow coma scale score; | — |
Countries
China
Contacts
Public ContactZhiying Chen
Affiliated Hospital of Jiujiang University
Outcome results
None listed