Intervertebral Disc Herniation
Conditions
Interventions
Observation Group of Intervertebral Disc Protrusion Syndrome:None
Sponsors
Affiliated hangzhou first people's hospital, zhejiang university school of medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients aged 18 and above, who have signed the informed consent form; 2. Meet the diagnostic criteria for cervical, thoracic, and lumbar intervertebral disc protrusion; 3. Plan to undergo surgical treatment, and during the operation, a nucleus pulposus sample can be obtained; 4. Can complete fecal and peripheral blood collection before the surgery.
Exclusion criteria
Exclusion criteria: 1.Recent use of antibiotics, probiotics, or other drugs/preparations that significantly affect gut microbiota; 2.Concurrent active infection, severe gastrointestinal dysfunction, tumor, immune system disease, spinal infection, pregnancy, severe hepatic or renal insufficiency, etc. 3.Prior history of spinal surgery, significant post-traumatic deformity, or congenital spinal deformity; 4.Predominantly manifesting as obvious myelopathy and not suitable for pain stratification; 5.Inability to cooperate with sample collection; 6.Unqualified nucleus pulposus, fecal, or blood samples;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in microbiota between nucleus pulposus samples and fecal samples; | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between microbiota and metabolites;Multivariable associations between microbiota, metabolites, and clinical baseline characteristics;Association between microbiota, metabolites, and VAS score;Multi-omics integrated analysis results of fecal microbiome, fecal metabolome, nucleus pulposus microbiome, nucleus pulposus metabolome, and nucleus pulposus transcriptome;Differences in the metabolome of nucleus pulposus, feces, and blood;Correlation between nucleus pulposus microbiota and fecal microbiota; | — |
Countries
China
Contacts
Public ContactHanbin Wang
Hangzhou First People's Hospital
Outcome results
None listed