Primary angle-closure glaucoma is the core disease studied in this research, and it is the leading cause of irreversible blindness among Asian populations. The fundamental pathological mechanism of this disease lies in the mechanical closure of the anterior chamber angle, a crucial structure responsible for aqueous humor drainage, leading to severe obstruction of aqueous humor drainage and continu
Conditions
Interventions
Group C: PEI + GSL + 120° goniosclerectomy group:Phacoemulsification cataract extraction combined with intraocular lens implantation + goniosyndactasia + 120° goniosclerectomy
Group A: PEI + GSL + 60° goniosclerectomy group:Phacoemulsification cataract extraction combined with intraocular lens implantation + goniosyndactasia + 60° goniosclerectomy
Group B: PEI + GSL + 90° goniosclerectomy group:Phacoemulsification cataract extraction combined with intraocular lens implantation + goniosyndactasia + 90° goniosclerectomy
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged 40-80, with no gender restrictions; 2.Meet the diagnostic criteria for advanced PACG; 3.Individuals with significant cataracts or those who require lens extraction as assessed by a clinician; 4.It is difficult to control the intraocular pressure to the target level with medication; 5.Patients provide informed consent, demonstrate good compliance, and are able to complete follow-up visits;
Exclusion criteria
Exclusion criteria: 1.History of intraocular surgery or ocular trauma (excluding laser iridotomy or laser iridoplasty; 2.The structure of the anterior chamber angle is unclear; 3.Incorporate other types of glaucoma, such as primary open-angle glaucoma and various types of secondary glaucoma; 4.Long-term local or systemic use of glucocorticoids or concurrent severe systemic diseases;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The success rate of intraocular pressure control at 12 months post-surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of anti-glaucoma medications used;Anterior chamber angle structural parameter (AOD500/TISA500);Best corrected visual acuity;Incidence of intraoperative and postoperative complications;Intraocular pressure values at various postoperative time points; | — |
Countries
China
Contacts
Public ContactGao Shasha
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed